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102nd Annual Meeting of the American Psychopathological Association
March 1-3, 2012 Grand Hyatt New York
Multigenerational transmission of psychopathology
The Cholmondeley Ladies, circa 1600-10
Multigenerational Transmission of Psychopathology
We are at the start of a new era of research on psychopathology, in which we will be tracing mental
disorders and their earliest antecedents across multiple generations. Since World War II, population-based pregnancy and birth cohorts have gradually illuminated the evolution of psychopathology over the life course, and have identified very early antecedents of mental disorders which later emerge in youth and adults. Yet, almost none of these cohorts has systematically studied the prenatal experience and early mental development of both the children and grandchildren of the cohort members. Recently, this has changed: a few cohorts have multigenerational studies in progress, and many others are planning to initiate them. At the same time, our understanding of how genetic and contextual (societal, family, cultural) causes of psychopathology and resilience are transmitted across generations is being transformed. This conference brings together investigators at the forefront of multigenerational studies with investigators at the forefront of related developments.
Ezra Susser, MD, DrPH, President 2012
Scientific Program
WEDNESDAY, 29 FEBRUARY 2012 Pre-Conference Trainee Meeting
12:30 – 5 PM Joint NIMH and NIDA T32 Trainee Meeting at the 102nd Annual Meeting of the APPA
8:00 – 9:30 PM “Here One Day,” a film by Kathy Leichter Screening sponsored by the Department of Epidemiology, Mailman School of Public Health, Columbia University
THURSDAY, 1 MARCH 2012
8:15 – 9:00 AM REGISTRATION and Coffee/Continental Breakfast
9:00 – 9:15 AM WELCOME AND OVERVIEW
Ezra Susser, MD, DrPH, APPA President
Columbia University and New York State Psychiatric Institute
SESSION 1 - Dynamic Parent-Offspring Relationships
Chair: Magdalena Cerdá, DrPH, MPH, Mailman School of Public Health, Columbia University
9:15 – 9:25 AM Presentation of Hoch Award to Myron Hofer, MD (by Ezra Susser, MD, DrPH)
9:25 – 9:40 AM “Why Are There Transgenerational Effects?"
Myron Hofer, MD, Columbia University
9:40 – 10:10 AM “What is Development?”
Thomas Insel, MD, National Institute of Mental Health
10:10 – 10:30 AM General Discussion
10:30 – 10:45 AM Break
SESSION 2 - Genes
Chair: Peter Szatmari, MD, McMaster University, Canada
10:45 – 11:15 AM “Anna Karenina and the Genetics of Mental Illness”
Mary-Claire King, PhD, University of Washington
11:15 – 11:25 AM Discussion
11:25 – 11:55 AM “Characterizing the Spectrum of Genetic Transmission of Psychopathology”
Shaun Purcell, PhD, Mount Sinai School of Medicine
11:55 – 12:05 PM Discussion
12:05 – 12:35 PM “Back to the Future: Testing New Theories in Traditional Pedigrees”
Matthew State, MD, PhD, Yale University
12:35 – 12:45 PM Discussion
12:45 – 1:00 PM General Discussion
1:00 PM – 2:30 PM LUNCH
SESSION 3 - Context
Chair: Jonathan Burns, FCPsych, MSc, University of KwaZulu-Natal, South Africa
2:30 – 3:00 PM “The Reproduction of Health Inequalities Across Generations”
Bruce Link, PhD, Columbia University and New York State Psychiatric Institute
3:00 – 3:10 PM Discussion
3:10 - 3:40 PM “Intergenerational Transmission of Child Abuse and Neglect”
Cathy Spatz Widom, PhD, City University of New York
3:40 – 3:50 PM Discussion
3:50 – 4:05 PM Break
4:05 – 4:35 PM “Increased Psychosis Incidence Across Generations of Immigrants:
A Tale of Us and Them”
Wim Veling, MD, PhD, Parnassia Psychiatric Institute, The Hague, and Maastricht University, The Netherlands
4:35 – 4:45 PM Discussion
4:45 – 5:00 PM General Discussion led by Joan Y. Chiao, PhD, Northwestern University
5:30 – 7:00 PM Poster Session Sponsored by Michael Lyons, PhD, Department of Psychology, Boston University
FRIDAY, 2 MARCH 2012
8:00- 8:50 AM Roundtable with Thomas Lehner, PhD, MPH, National Institute of Mental Health
(for early career and new investigators)
8:30-9:00 AM REGISTRATION and Continental Breakfast
SESSION 4 - Multigenerational Cohorts
Chair: Stephen Buka, ScD, Brown University
9:00 - 9:10 AM Presentation of Zubin Award to Zena Stein (by Ezra Susser)
9:10 - 9:30 AM “Measured Intelligence in Children: Antecedents and Follow-Ups”
Zena Stein, MB, BCh, Columbia University
9:30 – 10:00 AM “Three-generation Data on Aboriginal People in Australia”
Fiona Stanley AC, MD, Professor, Telethon Institute for Child Health Research, Perth, Western Australia
10:00 – 10:10 AM Discussion
10:10 – 10:40 AM “Transgenerational Influences on Health and Disease in the ALSPAC
Cohort”
George Davey Smith, MD, DSc, University of Bristol, United Kingdom
10:40 – 10:50 AM Discussion (opening remarks by Terry Bruha, MD)
10:50 – 11:05 AM Break
11:05 – 11:35 AM “Birth to Twenty Plus Cohort in South Africa”
Shane Norris, PhD, University of Witwatersrand, South Africa
11:35 – 11:45 AM Discussion
11:45 – 12:05 PM General Discussion
12:10 - 12:40 PM APPA Annual Business Meeting (members only)
12:40 - 2:10 PM LUNCH
SESSION 5 - Paternal Epigenetic Transmission
Chair: Karestan Koenen, PhD, Mailman School of Public Health, Columbia University
2:15 – 2:45 PM “Protective Adaptation by Heritable Epigenetic Modifications”
Jelena Mann, PhD, Newcastle University, United Kingdom
2:45 – 2:55 PM Discussion
2:55 - 3:25 PM “Paternal Transmission of Phenotype: Evidence from Animal Models”
James Curley, PhD, Columbia University
3:25 – 3:35 PM Discussion
3:35 – 3:50 PM Coffee Break
3:50 – 4:20 PM “The Trail of Risk for Developmental Disorders: The Fathers’ Story”
Avi Reichenberg, PhD, Kings College London, United Kingdom
4:20 – 4:30 PM Discussion
4:30 – 4:50 PM General Discussion
SATURDAY, 3 MARCH 2012
8:30 – 9:00 AM Registration and Continental Breakfast
9:00 – 9:05 AM Presentation of Robins/Guze Award
9:05 – 9:10 AM President’s Special Award to Gary A. Heiman, PhD, Rutgers University
SESSION 6 - A Platform for the Future
Chair: Ted Reichborn-Kjennerud, MD, Norwegian Institute of Public Health, Norway
9:10 – 9:40 AM “When the Whole Country Is a Cohort”
Camilla Stoltenberg, PhD, Norwegian Institute of Public Health, Norway
9:40 – 9:50 AM Discussion
SESSION 7 - Hamilton Lecture
9:50 – 10:00 AM Presentation of Hamilton Award to Ezra Susser (by Bruce Link, PhD)
10:00 – 10:30 AM “Multigenerational Effects of Preventive Interventions”
Ezra Susser, MD, DrPH, APPA President,
Columbia University
and New York State Psychiatric Institute 10:30 – 10:45 AM Discussion
10:45 – 11:00 AM Break
SESSION 8 - Kernels of Things to Come
Chair: Thomas G. Schulze, MD, University of Göttingen, Germany
11:00 – 11:20 AM “The Next Generation of the Multigenerationals”
Myrna Weissman, PhD, Columbia University and New York State Psychiatric Institute
11:20 – 11:40 AM “Two Step Epigenetic Mendelian Randomization in Multigenerational Studies”
Caroline Relton, PhD, Newcastle University, United Kingdom
11:40 – 12 NOON General Discussion
12 NOON ADJOURN
The American Psychopathological Association gratefully acknowledges the Division of Epidemiology, Services and Prevention Research at the National Institute on Drug Abuse (NIDA) for their generous support to this year’s Travel Awardees so they could attend our Annual Meeting. We gratefully acknowledge the Department of Epidemiology, Mailman School of Public Health, Columbia University, for its sponsorship of this year's film screening, Friday Roundtable and President's Reception. We also gratefully acknowledge sponsorship of this year's Poster Session by Michael Lyons, PhD, Department of Psychology, Boston University.
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